HAN00528

CDC Health Alert Network Advisory 00528 (HAN 00528) was issued by the CDC on 8 May 2026, requiring US healthcare facilities to implement airborne infection isolation precautions for any patient with suspected Andes hantavirus infection. It is the CDC's first HAN advisory specifically addressing Andes virus person-to-person transmission risk in a US clinical context.

HAN 00528 sits within the Health Alert Network tiered communication system, which the CDC uses to rapidly disseminate urgent public health information to clinicians, public health officials, and healthcare facilities. The HAN tier hierarchy runs: Health Alert (most urgent, immediate action required) → Health Advisory (important guidance, action recommended) → Health Update (updated information, no immediate action required) → Health Information (general interest). HAN 00528 is classified as a Health Advisory, the second-most urgent tier — reflecting the precautionary rather than confirmed-chain-transmission basis of the guidance. The advisory was triggered by the MV Hondius cluster in which Andes virus — the sole hantavirus with documented human-to-human transmission — was confirmed in a returning passenger.

The advisory's practical effect was to require US hospitals to place Andes-suspected patients under negative-pressure room isolation rather than standard contact-and-droplet precautions, pending further evidence on transmission dynamics. HAN advisories are not legally binding but are adopted as operational standard in federally funded and accredited health systems.