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Pandemics and Biosecurity
21JUL

Mpox clade Ib now spreads in Europe

3 min read
09:12UTC

Mpox clade Ib is circulating locally among men who have sex with men in Europe with no Africa travel history, the first confirmed local clade I transmission on the continent. All 23 US cases stay travel-linked.

ScienceDeveloping
Key takeaway

Mpox clade Ib is now transmitting locally in Europe for the first time, weeks before World Cup crowds gather.

Mpox clade Ib is now circulating locally among men WHO have sex with men in Europe with no African travel history, the first confirmed local clade I transmission on the continent 1. mpox, formerly called monkeypox, comes in genetic lineages called clades; clade I has historically been the more severe and was confined to central Africa until recently. Local transmission means European cases are catching the virus from each other rather than importing it from abroad, an advance on the recombinant clade Ib/IIb strain tracked across four countries in May .

In the United States, all 23 confirmed clade I cases remain travel-linked, and the CDC expects numbers to rise with World Cup travel as crowds gather across the host nations from mid-June. The ECDC and UK Health Security Agency are watching whether existing Jynneos vaccine stocks, validated against earlier strains, hold against clade Ib.

This mpox signal and the Dermatophilus congolensis cluster surface in the same surveillance window and the same Community, but they are independent pathogens, a virus and a bacterium, with no causal link between them. Both appear here because sexual-health screening in this Community is among the densest anywhere, not because they share an outbreak or a cause. Reading them as one phenomenon would be a category error.

Deep Analysis

In plain English

Mpox (monkeypox) comes in different genetic versions called clades. Clade Ib has been circulating in central Africa, including DRC, since late 2024. What is new this week is that clade Ib has been confirmed spreading between people in Europe, men who have sex with men with no recent travel to Africa. That makes this the first time this particular version of mpox has established local transmission outside Africa. In the United States, all 23 confirmed clade I cases were caught in travellers. The CDC expects more cases as the FIFA World Cup brings millions of people together. These mpox cases are a completely separate finding from the Dermatophilus bacterium cases also reported this week. They are caused by different organisms with no link between them; the only connection is that both were detected in the same surveillance window.

What could happen next?
  • Risk

    Clade Ib European local transmission confirmed ahead of the World Cup creates a global mixing event during which clade Ib may seed new metropolitan chains in countries without established mpox surveillance or JYNNEOS vaccination coverage.

  • Meaning

    Europe now has two concurrent mpox surveillance challenges: clade IIb (the 2022 lineage) and clade Ib (the DRC lineage), which require differentiated genomic surveillance to distinguish, since both present with similar clinical features.

First Reported In

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