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H5N1

Highly pathogenic avian influenza subtype; infecting US dairy cattle since 2024, now resurging in Idaho in May 2026.

Last refreshed: 7 May 2026 · Appears in 1 active topic

Key Question

With Idaho dairy cattle infected and aerosol evidence established, is H5N1 PPE guidance dangerously out of date?

Timeline for H5N1

#11 May

Detected in Idaho dairy herds, ending a five-month absence of US dairy cattle detections

Pandemics and Biosecurity: Idaho dairy H5N1 breaks five-month US lull
#11 May
#11 Feb

Killed a Bangladesh child on 1 February via household poultry contact; caused 3 Cambodian human cases in 2026

Pandemics and Biosecurity: Bangladesh and Cambodia keep the poultry H5N1 line
View full timeline →
Common Questions
Is H5N1 bird flu spreading in US dairy farms in 2026?
Yes. H5N1 was confirmed in Idaho dairy cattle in May 2026, the first US dairy detection since Wisconsin in December 2025. An Emory study found the virus in submicron aerosol particles in milking-parlour air.Source: CIDRAP
Can dairy workers catch H5N1 from breathing air on dairy farms?
An Emory University PLOS Biology study detected H5N1 in submicron aerosols in milking-parlour air on infected farms. Current CDC guidance focuses on contact precautions but does not address aerosol respiratory exposure.Source: PLOS Biology / Emory
How many people have caught H5N1 from cows in the US?
71 human H5N1 cases in the US have been recorded, all in dairy or poultry workers, with no community spread. PAHO logs 75 cumulative cases in the Americas since 2022 across 5 countries.Source: PAHO / CDC
Is there an H5N1 vaccine being developed in 2026?
Yes. CEPI announced on 22 April 2026 that Moderna had started the first Phase 3 trial of an mRNA H5N1 vaccine, the furthest any H5N1 mRNA candidate has reached in clinical development.Source: CEPI
What happened in Bangladesh and Cambodia with H5N1 in 2026?
A child in Bangladesh died in February 2026 after household poultry contact; Cambodia logged 3 human H5N1 cases in 2026. Both involve traditional poultry exposure, not the dairy-cattle pathway seen in the US.Source: CIDRAP

Background

H5N1 is a subtype of highly pathogenic avian influenza A (HPAI) virus that has circulated in wild birds and poultry since the late 1990s and represents one of the most closely watched pandemic-risk pathogens. The clade 2.3.4.4b has been responsible for a globally unprecedented spread across wild bird and mammalian species since 2021. In humans, H5N1 has historically had a case-fatality rate above 50% in confirmed clinical cases, though outbreak ascertainment bias makes the true rate uncertain. The virus has infected dairy cattle in the US since March 2024, a mammalian transmission pathway not previously seen at scale. WHO monitors H5N1 via the GISRS network; USDA tracks animal-side detections through the APHIS HPAI dashboard.

H5N1 (clade 2.3.4.4b B3.13) has been detected in US dairy cattle in Idaho as of May 2026, the first US dairy detections since Wisconsin in December 2025, breaking a five-month lull. An Emory University PLOS Biology study found the virus in submicron aerosol particles in milking-parlour air across 14 California farms, and in the exhaled breath of cows before clinical signs appeared. The clade in the air samples matches the one behind 71 known US human H5N1 cases. PAHO logged 75 cumulative human cases in the Americas since 2022, with no new human cases since November 2025 as of its March 2026 update. Moderna began the first Phase 3 H5N1 mRNA vaccine trial in April 2026 via CEPI.

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